Detailed view for Tb927.6.5120

Basic information

TDR Targets ID: 17792
Trypanosoma brucei, 60S acidic ribosomal protein P2, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 3.8968 | Length (AA): 107 | MW (Da): 10445 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00428   60s Acidic ribosomal protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006414   translational elongation  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126845)

Species Accession Gene Product
Arabidopsis thaliana AT2G27710   60S acidic ribosomal protein P2-2
Arabidopsis thaliana AT3G44590   60S acidic ribosomal protein P2-4
Arabidopsis thaliana AT3G28500   60S acidic ribosomal protein P2-3
Arabidopsis thaliana AT5G40040   60S acidic ribosomal protein P2-5
Arabidopsis thaliana AT2G27720   60S acidic ribosomal protein P2-1
Babesia bovis BBOV_III006260   60S acidic ribosomal protein P2 (L12EI)
Brugia malayi Bm1_49630   60S acidic ribosomal protein P2
Brugia malayi Bm1_39555   60s Acidic ribosomal protein
Candida albicans CaO19.5928   cytosolic ribosomal large subunit acidic protein P2B similar to S. cerevisiae RPP2B (YDR382W)
Candida albicans CaO19.13349   cytosolic ribosomal large subunit acidic protein P2B similar to S. cerevisiae RPP2B (YDR382W)
Caenorhabditis elegans CELE_Y62E10A.1   Protein RLA-2
Caenorhabditis elegans CELE_C37A2.7   Protein C37A2.7
Cryptosporidium hominis Chro.20020   acidic ribosomal protein P2
Cryptosporidium parvum cgd2_130   60S acidic ribosomal protein LP2
Dictyostelium discoideum DDB_G0283393   60S acidic ribosomal protein P2
Drosophila melanogaster Dmel_CG4918   Ribosomal protein LP2
Echinococcus granulosus EgrG_000736400   60S acidic ribosomal protein P2
Entamoeba histolytica EHI_186830   60S acidic ribosomal protein P2, putative
Entamoeba histolytica EHI_179980   60S acidic ribosomal protein P2, putative
Entamoeba histolytica EHI_138770   60S acidic ribosomal protein P2, putative
Echinococcus multilocularis EmuJ_000736400   60S acidic ribosomal protein P2
Giardia lamblia GL50803_16588   Hypothetical protein
Homo sapiens 6181   ribosomal protein, large, P2
Leishmania braziliensis LbrM.30.3760   60S acidic ribosomal protein P2, putative
Leishmania braziliensis LbrM.15.1150   60S acidic ribosomal protein P2
Leishmania donovani LdBPK_151190.1   60S acidic ribosomal protein P2
Leishmania donovani LdBPK_151200.1   60S acidic ribosomal protein P2
Leishmania donovani LdBPK_303780.1   60S acidic ribosomal protein P2, putative
Leishmania infantum LinJ.30.3790   60S acidic ribosomal protein P2, putative
Leishmania infantum LinJ.15.1200   60S acidic ribosomal protein P2
Leishmania infantum LinJ.30.3780   60S acidic ribosomal protein P2, putative
Leishmania infantum LinJ.15.1190   60S acidic ribosomal protein P2
Leishmania major LmjF.30.3730   60S acidic ribosomal protein P2, putative
Leishmania major LmjF.30.3720   60S acidic ribosomal protein P2, putative
Leishmania major LmjF.15.1203   60S acidic ribosomal protein P2
Leishmania major LmjF.15.1207   60S acidic ribosomal protein P2
Leishmania mexicana LmxM.29.3730   60S acidic ribosomal protein P2, putative
Leishmania mexicana LmxM.29.3720   60S acidic ribosomal protein P2, putative
Leishmania mexicana LmxM.15.1203   60S acidic ribosomal protein P2
Leishmania mexicana LmxM.15.1207   60S acidic ribosomal protein P2
Loa Loa (eye worm) LOAG_12589   60S acidic ribosomal protein
Loa Loa (eye worm) LOAG_11144   hypothetical protein
Mus musculus ENSMUSG00000025508   ribosomal protein, large P2
Neospora caninum NCLIV_053940   60S acidic ribosomal protein P2, related
Oryza sativa 4329540   Os02g0529700
Oryza sativa 4338938   Os05g0445500
Oryza sativa 4326782   Os01g0191100
Oryza sativa 9268174   Os07g0251301
Onchocerca volvulus OVOC727   60S acidic ribosomal protein P2 homolog
Plasmodium berghei PBANKA_0407700   60S acidic ribosomal protein P2, putative
Plasmodium falciparum PF3D7_0309600   60S acidic ribosomal protein P2
Plasmodium knowlesi PKNH_0833100   60S acidic ribosomal protein P2, putative
Plasmodium vivax PVX_119587   60S acidic ribosomal protein P2, putative
Plasmodium yoelii PY02905   60S acidic ribosomal protein P2
Saccharomyces cerevisiae YDR382W   ribosomal protein P2B
Saccharomyces cerevisiae YOL039W   ribosomal protein P2A
Schistosoma japonicum Sjp_0217340   ko:K02943 large subunit ribosomal protein LP2, putative
Schistosoma mansoni Smp_029820   60S ribosomal protein P2
Schmidtea mediterranea mk4.000762.01   Putative 60s acidic ribosomal protein P2
Trypanosoma brucei gambiense Tbg972.6.4920   60S acidic ribosomal protein P2, putative
Trypanosoma brucei gambiense Tbg972.9.3010   60S acidic ribosomal protein, putative
Trypanosoma brucei gambiense Tbg972.6.4930   60S acidic ribosomal protein P2, putative
Trypanosoma brucei Tb927.6.5130   60S acidic ribosomal protein P2, putative
Trypanosoma brucei Tb927.6.5120   60S acidic ribosomal protein P2, putative
Trypanosoma brucei Tb927.9.5690   60S acidic ribosomal protein, putative
Trypanosoma congolense TcIL3000_9_1910   60S acidic ribosomal protein, putative
Trypanosoma congolense TcIL3000_6_4580   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.506595.100   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.509165.40   60S acidic ribosomal protein P2 beta (H6.4), putative
Trypanosoma cruzi TcCLB.505977.26   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.510643.140   60S acidic ribosomal protein P2, putative
Toxoplasma gondii TGME49_309810   ribosomal protein RPP2
Theileria parva TP02_0370   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_464040   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_499760   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_220300   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_411440   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_384610   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_402500   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_291690   60S acidic ribosomal protein P2, putative

Essentiality

Tb927.6.5120 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.5120 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.5120 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.5120 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.5120 this record Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.4200 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.4200 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.4200 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.160.4200 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y62E10A.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y62E10A.1 Caenorhabditis elegans slow growth wormbase
CELE_C37A2.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_C37A2.7 Caenorhabditis elegans slow growth wormbase
CELE_C37A2.7 Caenorhabditis elegans sterile wormbase
PBANKA_0407700 Plasmodium berghei Essential plasmo
TGME49_309810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) increased (PATO:0000470) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.6.5120 (Trypanosoma brucei), 60S acidic ribosomal protein P2, putative
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